Determinants of infarct size in reperfusion therapy for acute myocardial infarction.
نویسندگان
چکیده
منابع مشابه
Determinants of infarct size in reperfusion therapy for acute myocardial infarction.
BACKGROUND Experimental animal studies have demonstrated that myocardium at risk, residual collateral flow, and duration of coronary artery occlusion are important determinants of final infarct size. The present study examined these variables in patients with acute myocardial infarction in relation to final infarct size. METHODS AND RESULTS Myocardium at risk was assessed with hexakis(2-metho...
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OBJECTIVES This study tested the hypothesis that first reducing myocardial work by unloading the left ventricle (LV) with a novel intracorporeal axial flow catheter while delaying coronary reperfusion activates a myocardial protection program and reduces infarct size. BACKGROUND Ischemic heart disease is a major cause of morbidity and mortality worldwide. Primary myocardial reperfusion remain...
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A cute thrombotic occlusion of a coronary artery usually produces myocardial ischemia that can result in myocardial infarction if reperfusion is not restored. Reperfusion injury from reintroduction of blood and oxygen into the ischemic area at risk can result in additional myocyte cell death (1,2). Whereas early reperfusion therapy has been shown to reduce infarct size by decreasing ischemic in...
متن کاملReperfusion therapy of acute myocardial infarction.
I N 1979, DUCKERT reviewed the completed trials of intravenous (IV) thrombolytic therapy in acute myocardial infarction (MI) for this journal.’ Duckert stated in his review, “It is fair to conclude that today the value of thrombolytic treatment of acute MI has not been established.” Since this review, dramatic advances have been made in the understanding of pathogenesis of MI, knowledge of thro...
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BACKGROUND The circadian clock influences a number of cardiovascular (patho)physiological processes including the incidence of acute myocardial infarction. A circadian variation in infarct size has recently been shown in rodents, but there is no clinical evidence of this finding. OBJECTIVE To determine the impact of time-of-day onset of ST segment elevation myocardial infarction (STEMI) on in...
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ژورنال
عنوان ژورنال: Circulation
سال: 1992
ISSN: 0009-7322,1524-4539
DOI: 10.1161/01.cir.86.1.81